Non-Viral Mediated Physical Approach for Gene Delivery
نویسندگان
چکیده
منابع مشابه
Targeted, non-viral gene delivery for cancer gene therapy.
The ability to mediate targeted and specific delivery of therapeutics to cancer cells remains one of the most important hurdles in effectively treating cancer. This aspect also remains as one of the greatest limitations of gene therapy as well. Targeted vectors based on the use of DNA-binding agents attached to cell specific ligands or "molecular conjugates" were created with the goal of over-c...
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Recent advances in molecular biology combined with the culmination of the Human Ge‐ nome Project [1] have provided a genetic understanding of cellular processes and disease pathogenesis; numerous genes involved in disease and cellular processes have been identi‐ fied as targets for therapeutic approaches. In addition, the development of high-throughput screening techniques (e.g., cDNA microarra...
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Chapter 1 describes the barriers that have hindered the effective use of gene delivery and a literature review of methods designed to overcome those barriers. Areas of gene delivery that will be discussed include viral, physical, and non-viral methods of gene delivery. A special focus will be on methods to target gene delivery vehicles and more specifically the somatostatin receptor 2 (SSTR2) t...
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Recently, there has been success in applying a semi-rational approach to non-viral gene delivery vector development using a combinatorial/parallel synthesis approach to construct libraries of materials with unique molecular structures. In this approach, it is hoped that the random incorporation of various hydrophobic and hydrophilic domains in the library will yield candidates with the appropri...
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background: mehr-80 is a newly established adherent human large cell lung cancer cell line that has not been transfected until now. this study aims to define the optimal transfection conditions and effects of some critical elements for enhancing gene delivery to this cell line by utilizing different non-viral transfection procedures. methods: in the current study, calcium phosphate (cap), deae-...
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ژورنال
عنوان ژورنال: Drug Designing: Open Access
سال: 2017
ISSN: 2169-0138
DOI: 10.4172/2169-0138.1000151